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Table 2 Studies included for qualitative synthesis

From: The burden of depressive disorders in musculoskeletal diseases: is there an association between mood and inflammation?

Authors Population Intervention Outcomes Findings and results
Fung et al. 466 healthy men Questionnaire about diet habit and correlation with other factors FFQs Major dietary patterns are predictors of plasma biomarkers of CVD and obesity risk
Shah et al. 1692 adult patients with inflammatory arthritis Retrospective longitudinal cohort study evaluating the effect of depressive treatment on pain SF-12v2, MCS, PCS Depression treatment didn’t improve pain and health-related quality of life among adults with arthritis
Apfelbacher et al. Adult patients with inflammatory arthritis Cross-sectional data from the 2002 World Health Survey Self-reported depression Positive association between inflammatory arthritis and depression in Western and Non-Western countries, suggesting that this relationship represents a universal phenomenon
Matcham et al. 56 RA patients One-year prospective study HADS Symptoms of depression and anxiety have implications for disease activity
Margaretten et al. 172 RA patients Evaluation of depression and health outcome HAQ, PHQ-9, DAS-28 Higher HAQ scores were associated with depression
Katz et al. 158 RA patients Cross-sectional study on sources of fatigue in RA patients Assessments of self-reported sleep quality, depression, physical activity, RA disease activity, muscle strength, functional limitations, body composition; information on demographics, medications, and smoking; the FSI Fatigue in RA patients is a result of RA disease activity, pain, inactivity, depression, obesity and poor sleep
Lu et al. 8831 RA patients and 15,456 health controls 14-year follow-up nationwide longitudinal study on bidirectional relationships between RA and depression Demographic variables, urbanization level, baseline comorbidities, incidence of depression A strong bidirectional relationships between RA and depression
Figueiredo-Braga et al. 82 RA patients, 73 SLE, 22 healthy subjects and 32 depressed control subjects Cross-sectional study FSS, HADS, PSQI, RAS, DAS28 IL-10 and IL-6 are associated with depressive symptoms
Hyphantis et al. 524 patients affected by RA, SLE, SSc, Glaucoma and Colon cancer Cross-sectional study to test the relative importance of depression in HRQOL in several chronic physical disorders SCL-90 and WHO Quality of Life Instrument Short Form, HRQOL SCL-90 somatization score significantly correlated to physical HRQOL in all diseases
  1. RA rheumatoid arthritis, PHQ-9 Patient Health Questionnaire-9, HADS Hospital Anxiety and Depression Scale, FFQs food-frequency questionnaires, CVD cardiovascular diseases, MR magnetic resonance, HAQ Health Assessment Questionnaire, DAS-28 Disease Activity Score 28, SCL-90 Symptom Distress Checklist, SLE systemic lupus erythematosus, SSc systemic sclerosis, HRQoL Health-Related Quality of Life, PsA psoriatic arthritis, SpA spondyloarthritis, TNF-α tumor necrosis factor α, SMDs standardized mean differences, FSI Fatigue Severity Inventory, AxSpA axial spondyloarthritis, SF-12v2 Short Form Health Survey-12 version two, MCS Mental Component Summary Score, PCS Physical Component Summary Score, FSS Fatigue Severity Scale, HADS Hospital Anxiety and Depression Scale, PSQI Pittsburgh Sleep Quality Index, RAS Relationship Assessment Scale, HADS Hospital Anxiety Depression Scale
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Annals of General Psychiatry

ISSN: 1744-859X